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The underlying pathogenic cause of peripheral neuropathy in these individuals is reduced pyruvate flux due to hyperphosphorylation of pyruvate dehydrogenase complex (36

doi: 10.1016/s1734-1140(13)71025-9 86 MarkusRPFernandesPAKinkerGSCruz-Machado S daSMarolaM

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Dietary zinc is absorbed primarily in the small intestine, particularly in the jejunum, where specialized membrane proteins mediate its uptake into enterocytes 25