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For example, mutations of the MTR or MTRR genes can affect the conversion of B12 to its active form, which affects the absorption of synthetic cobalamin in the body

These individuals benefit most from injectable B12 supplementation, whether through their tirzepatide formulation or separate B12 injections

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In fact, recent studies showed that interference with N-linked glycosylation rather than glycolysis as the predominant mechanism by which 2-DG inhibits cancer cell growth under normoxia 27,28,29