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Against this background, this review provides an overview of the structure and function of the bloodbrain barrier and discusses the abnormal changes in the BBB in different CNS diseases

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This suggests that the gut macrobiotic and its metabolites are engaged in the progression of atherosclerosis, and also that dysbiosis of gut flora is linked with systemic inflammation (Drosos et al., 2015)

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In Britain, the British National Formulary (BNF) recommends 1 mg IM OH-Cbl 3 times a week for 2 weeks and then maintenance 1 mg IM OH-Cbl every 3 months in patients without neurological involvement

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