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10.1146/annurev-pathmechdis-012419-032711 24 ChandraG.KunduM.RangasamyS

(2024) 11:e2308208

Key Facts About CPT 82746 Service type: Clinical laboratory blood test Provider type: Physicians, laboratories, and qualified healthcare professionals Medical services included: Quantitative measurement of serum folic acid Specimen type: Blood (serum) Common clinical indications: Evaluation of macrocytic or megaloblastic anemia Assessment of nutritional deficiencies Monitoring malabsorption syndromes (e.g., celiac disease, IBD) Neurologic symptoms potentially related to vitamin deficiency Monitoring patients on medications affecting folate metabolism When to Use CPT 82746 CPT 82746 is appropriate when: A blood sample is collected to measure serum folate levels The test is medically necessary for diagnostic evaluation or ongoing monitoring Results will influence clinical decision-making, supplementation, or treatment plans Examples: Evaluating unexplained anemia with elevated MCV Monitoring folate status in patients with chronic gastrointestinal disease Assessing nutritional deficiencies in integrative or functional medicine care Evaluating neurologic symptoms such as neuropathy or cognitive changes Documentation Requirements To support accurate billing for CPT 82746, documentation should include: Patient identifiers and date of specimen collection Ordering provider and clinical indication for testing Confirmation that a serum folic acid test was performed Test results and reference ranges Follow-up actions, treatment plans, or supplementation recommendations Clear documentation supports medical necessity, payer compliance, and continuity of care , especially when tracking nutritional markers over time