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[DOI] [PubMed] [Google Scholar] 11.Trixl L, Amort T, Wille A, Zinni M, Ebner S, Hechenberger C, Eichin F, Gabriel H, Schoberleitner I, Huang A, et al

However, numerous studies indicate that individuals with ME/CFS experience increased intestinal permeability, supporting the theory that Gram-negative bacterial endotoxins, also known as LPS, may enter the mesenteric lymph nodes and the blood stream through the loosening of tight-junction proteins (e.g., Zonulin), triggering an immune response and resulting in systemic inflammation [10, 21, 24, 39,40,41,42]

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For the analysis of anti-GX-G3 antibodies, blood was collected from rats on weeks 0 (pre-dose), 2 (Day 14), 4 (Day 28), and 8 (Recovery day 29) and from monkeys on weeks 0 (Day 1), 1 (Day 8), 3 (Day 22), 4 (Day 29) and 8 (Recovery day 30)