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doi: 10.1172/JCI28075 12 TaoHWLiuZYJiangWMiaoMYLyuJQZhaoMet al

2002Chinese Multicenter RCT Design Multicenter, randomized, double-blind, placebo-controlled trial

Reconstitution Add 1mL sterile or bacteriostatic water to each 10 IU vial Final concentration: 1 IU = 0.1mL (10 units) Dosing Standard dose range : 2 IU to 6 IU daily (2060 units) Start low and titrate based on labs and response Cycling Protocols Option 1: 5 days on / 2 days off (e.g., MonFri on, SatSun off) Option 2: 3 days on / 1 day off (continuous rotation) These cycling patterns help mimic the bodys pulsatile release and reduce desensitization or side effects