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Conditions such as severe kidney disease or congestive heart failure affect fluid and electrolyte handling in ways that require additional medical clearance before IV therapy is considered safe

Peterschmitt MJ, Saiki H, Hatano T, Gasser T, Isaacson SH, Gaemers SJM, Minini P, Saubadu S, Sharma J, Walbillic S, Alcalay RN, Cutter G, Hattori N, Hglinger GU, Marek K, Schapira AHV, Scherzer CR, Simuni T, Giladi N, MOVES-PD Investigators (2021) Safety, pharmacokinetics, and pharmacodynamics of oral venglustat in patients with Parkinsons disease and a GBA mutation: results from part 1 of the randomized, double-blinded, Placebo-Controlled MOVES-PD trial

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The activity results showed that diterpene alkaloid malonganenone D had a strong inhibitory effect on the enzymatic activity of c-Met

10.1002/adbi.202210065 261 YamazakiC