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There is evidence that [Ca2+]i increases in glaucomatous RGCs occur in dendrites and somata (121), which might account for the increased ER stress and Ca2+-dependent signals (immediate early genes (c-fos, JNK2/3, CREB), proteases, caspases and MAP kinases) in glaucomatous RGCs

High-throughput screening of natural products for cancer therapy

It can activate tumor-suppressive signaling pathways while inhibit proliferation and differentiation-related signaling pathways, ultimately induce tumor cell differentiation and increase sensitivity to DOX, result in an enhanced therapy effect

In doing so, it promotes correct SOD1 folding and zinc binding

Mitochondrial dysfunction, oxidative stress and inflammatory response are the common upstream pathogenesis of various ovarian diseases