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Furthermore, in animal models, glycyrrhizin has been shown to inhibit the activation of hepatic stellate cells (HSCs) and induce their apoptosis by blocking NF-B nuclear translocation, thereby preventing liver fibrosis (Qu et al., 2012)

The article discusses the pharmacokinetic challenges peptides face, such as low oral bioavailability due to poor membrane permeability and enzymatic degradation in the gastrointestinal tract

Acknowledgments The authors would like to thank all those who contributed to this article