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But that flexibility demands precision

In addition, artemisinin, through mechanisms such as increasing drug loading, enabling rapid reactive release, and optimizing drug delivery sequence, can efficiently and precisely address the multidrug resistance in breast cancer (MCF-7 and LCC9) cells [117, 120]

To test whether TNR follows such a pathway, we labeled newly O-glycosylated proteins by feeding the neurons with azide-modified galactosamine (GalNAz) and glucosamine (GlcNAz), which were then revealed by tagging with a fluorophore, using a click chemistry reaction 36

When this binding is inhibited, bile acid synthesis and secretion into the intestine continues, which leads to diarrhea (Farrugia & Arasaradnam, 2021)

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