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De Meyts P, Whittaker J (2002a) Structural biology of insulin and IGF1 receptors: implications for drug design

2017 Sep 28;118(6):45462

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Reviews of the rodent work note that the mechanism doesnt involve the hormonal suppression or receptor desensitization that would predict tolerance or rebound, and that adipose SAM levels tend to normalize rather than crash under inhibition