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Infertility and birth defects: these can affect menstrual cycles and lead to complications in pregnancy (Tudosa et al

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Laboratory studies demonstrate that ES2 peptides show 3-7 times more potent senolytic activity than FOXO4-DRI in both in vitro and in vivo experimental systems, while CPP-CAND demonstrates approximately 1.2-fold higher selectivity despite shorter peptide length

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Some researchers describe this as creating lasting changes in synaptic architecture, not just a transient neurochemical boost