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FIGURE 2 The results of biochemical and structural analyses revealed the overall structure of Keap1Nrf2 complex under the normal condition

doi: 10.1016/j.ecl.2020.05.007

Thus, acne can be considered as a visible model disease of exaggerated IIS during puberty aggravated by Western diet, just the opposite of deficient IIS in untreated Laron subjects who do not develop acne [19]