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4.2.1.3 Vitamin A Vitamin A and -carotene are important antioxidants as they interfere with the process of peroxidation

D.IwarM

120 (25), e2218896120

When folate levels are significantly decreased, the 5-MTHF metabolic pathway is blocked and the SAMe/SAH ratio is down-regulated, which inhibits methyltransferase activity and disrupts DNA methylation homeostasis thus leading to delayed closure of the neural tube, and ultimately to the formation of neural tube defects (NTDs) (105)