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Subsequently, the mitochondrial permeability transition pore (MPTP) located on the mitochondrial membrane opens, allowing small solutes to enter the mitochondrial matrix, leading to mitochondrial dysfunction and cell apoptosis

Whereas, FsC and TAFC are produced under iron starvation to be excreted for chelation and import of ferric iron, FC and HFC act as intracellular storage and transport vehicles 22,57

Upon transportation into astrocytes, glutamate either follows the glutamine synthase pathway, wherein it converts into glutamine, or enters the TCA cycle where it converts to -ketoglutarate, a substrate for ATP production (Waniewski and Martin, 1986)

Cells that are better able to defend against oxidation will have a higher score