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Lastly, studies systematically identifying Mn exposure limits based on age, sex, and exposure duration as well as changes in signaling cascades associated with metal homeostasis and protein aggregation need to be conducted

Future studies should test whether NRF2 activation can effectively reduce PC and preserve functional -cells in diabetes

Although zebrafish liver disease models are widely employed, a dedicated methodological synthesis evaluating their application specifically for phytochemical researchfrom model establishment to mechanistic validationis lacking

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