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J.CastleD.et al

Conversely, deubiquitinases/DUBs remove ubiquitin chains from substrate proteins, counteracting the activity of E3 ligases, thereby stabilizing the targeted proteins

Excessive ionophore administration can overwhelm these defenses, leading to systemic copper poisoning, characterized by hepatotoxicity, nephrotoxicity, and hematopoietic suppression [239]

When compared with the other H 2 O 2 scavenger enzymes, CAT seems to be the key enzyme to remove high intracellular concentrations of H 2 O 2 [32, 53, 59, 60]

The activity of the antioxidant enzyme GPx was determined by standard protocols, in blood samples (2 ml each), collected from all subjects, after the onset of arrhythmia (for groups I and II), by venipuncture (in K2EDTA vacutainers), using a standardized Ransel Laboratory kit (RandoxLaboratories, Ltd.)