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Data availability The data in this study will be made publicly available according to publication date in the Gene Expression Omnibus (GEO) under accession no

& Domingues, L

18 , eadn9868 (2025)

Other adverse effects include thrombocytopenia and cardiovascular complications such as congestive heart failure and hypotension [53]

For example, while low-dose polyphenols stimulate endogenous antioxidant defenses, high concentrations, such as those found in concentrated supplements, can act as potent pro-oxidants, leading to increased oxidative stress and cellular damage 51