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The overall biosynthetic pathway of isoprostanes involves the formation of arachidonyl radicals and peroxyl radical isomers with endocyclization, forming bi-cycloendoperoxide regiomers reduced to F2-isoprostanes (F2-IsoPs)

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Key perioperative risk domains relevant to TJA and implant-based surgery potentially affected by peptide exposure are summarized in Table 4

Results vary between individuals, and the same effects cannot be guaranteed for all patients