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In conclusion, gut microbial metabolites, regulated by host genetics/diet/environment, mediate DM multi-organ damage via gut-lung axis mechanisms

doi: 10.1016/j.clim.2019.02.005 179 BranzkNLubojemskaAHardisonSEWangQGutierrezMGBrownGDet al

Since the linker does not contain a solubilizer, achieving such a high DAR is very impressive, as it contradicts the widely established principle that high DAR conjugates may have poorer pharmacokinetic profiles