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Moreover, the treatment should be able to reach the central nervous system, which is a difficulty for both drugs (must cross the bloodbrain barrier or be administered intrathecally) [263] and devices (surgical access to the CNS might be required)

Oxidative stress homeostasis in grapevine ( Vitis vinifera L.)

Dennis DL & Fletcher WS (1966) Toxicity of sodium thiosulfate (NCS-45624), a nitrogen mustard antagonist, in the dog

Yu L, Wei J, Liu P

That system can break down if you: Take acid blockers (PPIs like omeprazole) or antacids regularly Have low stomach acid from age or chronic stress Have had GI surgery (gastric bypass, bowel resection) Live with conditions like celiac, Crohns disease, or IBS Have autoimmune pernicious anemia Even with high-dose tablets (e.g., 1000 mcg), only a small fraction may reach your bloodstream