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In fact, it was demonstrated that Erastin can potentially activate VDAC channel [50], which results in mitochondrial disruption [51] and lead to apoptotic cell death in gastric [52] and colorectal cancer cells [34]

initially synthesized the first SB by treating chitosan using multiple aldehydes in a solvent of acetic acid and methanol (Hirano et al., 1977)

2.3 The relationship between ferroptosis and other programmed cell death responses Ferroptosis is intricately linked to biological processes, including autophagy, endoplasmic reticulum stress, and inflammation, among others, and may be involved in the reciprocal regulation of recalcitrant diseases

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Assessment and analysis To assess the clinical response photographs were taken at the beginning of the therapy (baseline, i.e., day 0, at each sitting [4th and 8th weeks], and after 4 weeks of last therapy, i.e., at 12th week