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Synthetic lethality in personalized cancer therapy

Knowing your BH4 profile helps explain and address deeper neurological imbalances

This process is thought to be due to accumulation of mutations in cancer-related genes, including oncogenes, tumor-suppressor genes, and DNA mismatch repair (MMR) genes

Am J Physiol Cell Physiol 281:C1495C1503 Lewerenz J, Maher P, Methner A (2011) Regulation of xCT expression and system x c function in neuronal cells

Thus, I, along with most progressive, integrative, and functional medicine physicians, will often recommend thyroid hormone treatment at this stage (some even advocate for treatment with thyroid medications during stage 2)