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This lipid A displays a unique structural feature, with a non-phosphorylated skeleton made up of the tetrasaccharide Man--(14)-GlcN3N--16-GlcN3N--(11)--GalA, and four primary amide-linked 14:0(3-OH) and, as secondary O-acyl substituents, a 16:0 and the very long-chain fatty acid 26:0(25-OAc), appended on the GlcN3N units

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Enhanced oxidative capacity may involve increased mitochondrial fatty acid uptake via carnitine palmitoyltransferase-1 (CPT-1), enhanced beta-oxidation enzyme expression, and modulation of uncoupling protein expression

doi: 10.5534/wjmh.180078 89 BulkeleyEAFoutouhiAWigneyKSantistevanACCollinsCMcNabbBet al

doi: 10.1016/j.jsps.2017.04.018 78