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As reported in one of the studies, there was a gradual loss of donor mtDNA in some of the ES cells derived from transplanted embryos

[DOI] [PMC free article] [PubMed] [Google Scholar] Zhang H, Wan GZ, Wang YY

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For instance, PS-NPs, with sizes comparable to cell membrane pore diameters (approximately 100 nm), can penetrate the BBB directly, invade the central nervous system, and interfere with neuronal function, making them a major focus of current research 11