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In one embodiment, the invention provides assays for screening candidate or test compounds which bind to or modulate the activity of the membrane-bound form of a NOVX protein or polypeptide or biologically-active portion thereof

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For instance, in the BRIDGE trial comparing DMF alone to a compound containing DMF plus other FAE, while both were significantly more effective than a placebo, there was no significant difference between them, indicating that DMF is the active ingredient in terms of efficacy