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Endocrine benefits were also observed, with increased insulin secretion and -cell proliferation

The blinding of subjects and researchers was reported in four studies (Reference Hashim, Anwar and El-Fatah22,Reference Nasr9,Reference Chandil, Pande and Sen27,Reference Gayatri, Kumar and Kumar28)

Therefore, with a well selected population that would diminish the 95% confidence interval of relative risk of cardiovascular disease, we suggest that there might be an increased cardiovascular risk in the MTHFR TT mutants when folate status is low

Dietary choline or trimethylamine N-oxide supplementation does not influence atherosclerosis development in Ldlr/ and Apoe/ male mice

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