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Androgen Network Modulation: LT decreased CYP11A1/CYP17A1 and elevated CYP19A1, showing upstream inhibition-downstream activation. LT also boosted -diversity, adjusted the F/B ratio, enriched Dubosiella / Muribaculum , and inhibited Lachnospiraceae and Alistipes

This role is critical for controlling membrane dynamics that define cell shape and polarity, the formation of membranous protrusions, and the motility of cellular processes 417,418

However, the excessive activation of ERS can also be detrimental to cells

Reactions of L-ergothioneine and some other aminothiones with 2,2-and 4,4-dipyridyl disulphides and of L-ergothioneine with iodoacetamide

elegans either promotes axonal fusion or leads to increased axonal debris