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or it may be secondary, in which the individual develops the condition because of other metabolic disorders The signs and symptoms of Carnitine Deficiency Syndrome may include irritability, fatigue, abnormal liver enlargement, and failure to thrive in children

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, However, it is unclear whether this mechanism contributes to the formation of TLS in vivo

As stated above, in addition to oxidative stress, DSBs in neurons may arise from increased transcription 68 , abnormal activity and cell cycle reentry 37,38,68,86,87