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The abundance of signal transducer and activator of transcription 3 (STAT3) in GBM has been demonstrated to promote AHR expression and cooperate with HIF-1 to increase CD40 levels, which in turn promoted GBM immune evasion and STAT4-mediated PD-L1 upregulation ( 3 TAM-targeting therapies for GBM The current standard GBM strategy is surgical resection combined with oral temozolomide (TMZ) and radiotherapy ( 3.1 TAM recruitment prevention As previously alluded to, M2 TAMs are implicated in GBM progression and invasion

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