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The highly frequent adverse eect was drowsiness

Moreover, both the hypo-phosphorylated 19 (all 15 Ser/Thr Cdk acceptor sites changed to Ala) and hyper-phosphorylated (S245D) pRB1 mutants were degraded by KLHL42 expression (Supplementary Fig

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A licensed registered nurse will administer and oversee the IV therapy