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Nutritional and lifestyle interventions A nutritionally optimized diet coupled with a balanced lifestyle exerts indispensable immunomodulatory effects through the potentiation of innate and adaptive immune responses, as well as the attenuation of chronic low-grade inflammation (inflammaging)

On the calcium side, altered expression of calcium-handling proteins, such as reduced sarcoplasmic reticulum Ca 2+ ATPase(SERCA2a) and dysfunctional ryanodine receptors, has been documented in failing human hearts, providing a mechanistic basis for impaired excitationcontraction coupling ( 3.4 Mitochondrial membrane potential imbalance In the context of HF, the ma critical bioelectrical gradient essential for maintaining mitochondrial function and myocardial energy metabolismis significantly disrupted (Schneider, 2011

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