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Clinical Application Prospects for Vagus Nerve Stimulation Therapy Despite the good animal and clinical evidence for targeted plasticity therapy with VNS in various neurological diseases and brain injuries, the large-scale clinical use of VNS still faces many difficulties and challenges owing to the individual variability of clinical patients and the diversity of comorbidities

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(2) WRW4/ASA group: rats were given WRW4 (0.3 mg/kg per day i.v.), an antagonist of FPR2/ALX receptor (Sordi et al., 2013) 5 min before ASA administration (30 mg/kg per day, by oral gavage)