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Li, X., He, S

While NAC is generally considered safe and well-tolerated, some individuals should avoid it, including: People with asthma (NAC may trigger bronchospasm)

MTX and NSAIDS A recent Cochrane systematic review by Colebatch and coworkers [53] evaluating 8621 studies documented that only 17 publications reported a concurrent use of MTX and NSAID, but none reported ADRs on lung, liver, or renal function and no increase in MTX withdrawal or in other major toxicity