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Research demonstrates that 5-Amino-1MQ exhibits high selectivity for NNMT and does not inhibit structurally related methyltransferases or other enzymes in the NAD+ biosynthesis pathway, including NAMPT and SIRT1

World J Gastroenterol 23:4658488 Farges M, Balcerzak D, Fisher B, Attaix D, Bchet D, Ferrara M, Baracos V (2002) Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis

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This process helps reduce damage to surrounding healthy tissue, making PDT a safer alternative to more invasive procedures