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Oral GLN dramatically increases the expression of the pro-apoptotic factor Bad and suppresses the expression of Bcl-2, according to the detection of the apoptosis pathway

Silva et al., 2023)

Two regimensguadecitabine combined with pembrolizumab (NCT02901899), and atezolizumab combined with guadecitabine and the CDX-1401 vaccine (NCT03206047)have completed enrollment, with results pending release