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MIC B12 is typically contraindicated during pregnancy and lactation without explicit obstetric approval

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Seek immediate medical attention if you experience any of the following while taking ibuprofen: Severe stomach pain or black, tarry stools Unexplained bruising or bleeding Dizziness, fainting, or rapid heartbeat Signs of allergic reaction, such as rash, swelling, or difficulty breathing Confusion, tremors, or unusual behavior (especially if on lithium or methotrexate) Even if symptoms are mild, consulting a healthcare professional can prevent complications

The evaluation determines the right starting point

(ii) biomarker-enriched, mechanism-aligned trials (e.g., bile-acidtargeted therapy for suspected bile-acid malabsorption in IBS-D)