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Arch Biochem Biophys 228:112 Pinto MC, Mata AM, Lopez-Barea J (1985) The redox interconversion mechanism of Saccharomyces cerevisiae glutathione reductase

Deamidation breaks the backbone Asparagine and glutamine residues in the tirzepatide sequence are vulnerable to deamidation, a chemical reaction where the amide group converts to a carboxylic acid