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Owing to their high oxygen consumption, skeletal muscle fibers are inherently prone to ROS generation during contraction and metabolism ( Elevated ROS also activate the NF-B pathway by depleting glutathione (GSH), downregulating myogenic transcription factors (MyoD, MyoG), and upregulating the transcriptional repressor Yin Yang 1 (YY1), thereby impairing myogenic differentiation (Xiang et al., 2022)

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Environ Toxicol Pharmacol 39:683689 Chung L-C, Chiang K-C, Feng T-H, Chang K-S, Chuang S-T, Chen Y-J, Tsui K-H, Lee J-C, Juang H-H (2017) Caffeic acid phenethyl ester upregulates N-myc downstream regulated gene 1 via ERK pathway to inhibit human oral cancer cell growth in vitro and in vivo

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