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Evaluation of myocardial substrate oxidation in isolated working hearts demonstrated increased rates of fatty acid oxidation (FAO) and decreased oxidation of glucose in various animal models of T2DM, including db/db mice, ob/ob mice, or Zucker diabetic fatty rats [2425]

The effect of yangonin on estrogen-induced hepatic cholestasis, an inflammatory disease of the liver, was explored in C57BL/6 mice [54,55]

Diabetes is a chronic metabolic disease characterized by insufficient insulin secretion from pancreatic -cells or impaired hepatic glucose regulation, including disruptions in the glycogen cycle [90,172,173]