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Current status: In 2024, the FDA removed TB-500 from 503B outsourcing facility compounding

PKM2 is primarily expressed in embryonic cells and NPCs in the hippocampus, cerebellum, and subventricular region (117)

A cure for PD has not been identified and the current therapy options are pharmaceutical- and/or surgical-based interventions to treat condition symptoms

SpreuxVaroquaux O., Bensimon G., Lacomblez L., et al., Glutamate Levels in Cerebrospinal Fluid in Amyotrophic Lateral sclerosis: A Reappraisal Using a New HPLC Method With Coulometric Detection in a Large Cohort of Patients, Journal of the Neurological Sciences 193, no