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While not listed as a direct adverse effect in FDA prescribing information, this cold sensitivity appears linked to the medication's weight loss effects rather than direct temperature regulation changes

Similar content being viewed by others Introduction Mycobacterium tuberculosis ( Mtb ), the causative agent of human tuberculosis (TB), is still a formidable human pathogen that, despite decades of research and widely available treatments, remains a leading cause of death globally (World Health, 2024)

The AES (Supplementary Note 1) were obtained using the BAC-knockouts as templates for a PCR using primers described in (Supplementary Table 2)

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