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Catalpol, a potent antioxidant and free radical scavenger acting through the ERK1/2 signaling pathway, has also been shown to positively affect NG2 glia (pre-myelinating oligodendrocytes) after oxidative stress (Cai et al., Mitochondrial Dysfunction The ischemia-induced excitotoxicity results in mitochondrial malfunctioning due to the damage to mitochondrial proteins, membranes, and DNA, thus impairing the ability of mitochondria to synthesize ATP and carry out their wide range of metabolic functions (Rama and Garca, 2016)

thaliana ortholog Ind1, which showed that it functions as a translation factor necessary for expression of multiple complex I subunits [56]

Role of mitochondrial dysfunction in hypertension and obesity

While GHK-Cu and TB-500 are studied for structural remodeling (collagen/actin), the inclusion of KPV (Lysine-Proline-Valine) adds a potent anti-inflammatory and antimicrobial dimension