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fewer solo practitioners with negative payment adjustments have a final score near the performance threshold and an increase in the final score of these MIPS eligible clinicians will reduce the size of their negative payment adjustment but is less likely to shift their final scores above the performance threshold in the manner described earlier

Their carried active components, such as proteins, nucleic acids, and lipids, are protected by a bilayer membrane structure and can be delivered to target cells via membrane fusion, participating in intercellular communication (Zhao et al., 2019)

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