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Serotonin and HPA Axis BPC-157 also interacts with the serotonin system and has been shown to influence corticotropin-releasing hormone (CRH) signaling in stress models

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The sarcoplasmic reticulum Ca+ channel RyR2 undergoes SSG under oxidative stress, which initially protects against calcium overload in ischemia-reperfusion injury, whereas it becomes maladaptive in sustained oxidative environments (e.g., catecholamine-induced arrhythmias) (80)