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With age the animals developed type 2 diabetes, underlining the metabolic consequences of largely elevated GH combined with circulating IGF-I deficiency (34)

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For mediation models we used the lavaan structural equation modelling (SEM) package, version 0.68 [34], with the MLR estimator (Maximum Likelihood estimation with Robust standard errors) and removed outlying values prior to analysis

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Superoxide Dismutase (SOD) A potent enzyme that defends against free radical damage and inflammation, preserving skin health at the cellular level