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The domain of G0S2 which inhibits PNPLA2 comprises amino acids K20-A52 and does not inhibit the function of other PNPLA family members PNPLA6 and 7, or HSL, MGL, and lipoprotein lipase (54)

Diabetes 59 , 14611468 (2010)

Several mitochondrial enzymes like aconitase and 1-galactono- lactone dehydrogenase (GAL) also contribute to ROS generation

Safety, tolerability, and pharmacokinetics of casimersen in patients with duchenne muscular dystrophy amenable to exon 45 skipping: a randomized, double-blind, placebo-controlled, dose-titration trial