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The kidneys cleanse the blood and ensure the components of the circulatory milieu stay within the narrow ranges necessary to support normal physiology

In contrast to its predominant oxidizing activity in the ER, surface-associated PDI acts primarily as a reductant

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Table 4 lists the top compounds with peak areas

Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies