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85 This is of particular importance because some xenobiotics might impact the GI microbiota physiology without inducing dysbiosis: indeed, when fresh human faecal samples were incubated with antibiotics or with host-targeted drugs, all host-targeted drugs resulted in significant alterations of microbial gene expression, including genes involved in xenobiotic metabolism, despite minimal short-term effects on microbial community structure

After incubation for 1 h at 20 C, the sample was centrifuged for 15 min at 16,200 g and 4 C

10.1093/jn/130.2.496S 147 SanoK.IwasakiY.YamashitaY.IrieK.HosokawaM.SatohK.et al (2021)