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Since ischemiahypoxia-induced neovascularization is a hallmark of DR progression, herbal agents such as erianthrine inhibit capillary regeneration in the posterior pole region of DR rats (112), while Vaccinium myrtillus, Lonicera japonica Flos suppress angiogenesis by downregulating PKC2 and modulating VEGF expression (113)

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Methylmalonic acid in urine is stable at room temperature, provided concentrated hydrochloric acid is added to the urine sample, and for several years, when urine specimens are frozen at 70C